OBJECTIVE: The objective was to study the
clinicopathologic features of rhabdomyosarcoma (RMS) of the oral
and maxillofacial region in Jordanians.
STUDY DESIGN: Data were collected from records of
patients treated between 1989 and 2000 at the Maxillofacial Unit
of Jordan University of Science and Technology. The main outcome
measures were age, gender, location, stage of disease,
histopathologic type, treatment received, follow-up period, and
RESULTS: Nine patients with RMS aged 4 to 17 years were
found, with a male to female ratio of 2:1. Six (67%) bony sites
and 7 (78%) soft tissue sites were involved. The extent of
disease was locoregional in 8 (89%) cases, nodal in 3 (33%)
cases, and distant metastatic in 2 (22%) cases. The Intergroup
Rhabdomyosarcoma Study classification of clinical groups was as
follows: 2 (22%) cases in stage II, 5 (56%) cases in stage III,
and 2 (22%) cases in stage IV. The histopathologic types found
were 6 (67%) embryonal, 2 (22%) alveolar, and 1 (11%)
undifferentiated. Triple agent chemotherapy was used in the
treatment of 8 cases, singly or in combination with surgery or
radiotherapy. Two patients are still alive, and 5 patients have
died of disease.
CONCLUSIONS: The clinicopathologic features of
maxillofacial RMS in this group of Jordanians are different from
those of people from other countries. Further studies are needed
to have a better understanding of the behavior of RMS in the
oral and maxillofacial area.
Jordan University of Science and Technology. Irbid, Jordan.