OBJECTIVE: Determination of Alpha1-antitrypsin
(alpha1-AT) phenotypes in Jordanian patients with lung,
prostate and breast cancer to find a prevalent phenotype that
could be recommended for the early diagnosis of cancer.
METHODS: This study was conducted at Jordan
University of Science and Technology, Irbid,
Jordan, during the period May 2001 to May 2002. Alpha1-AT
phenotypes for 83 Jordanian cancer patients distributed
as follows, 25 lung cancer, 25 prostate cancer and 33 with
breast cancer, were tested using isoelectric focusing gel
electrophoresis and immunofixation techniques.
RESULTS: Isoelectric focusing results demonstrated that
96% of lung cancer patients were of PiMM phenotype and 4% of
PiFM phenotype. All prostate cancer patients (100%) were found
to be of PiMM phenotype. Phenotypes of breast cancer patients
were 94% PiMM, 3% PiFM and 3% PiMS.
CONCLUSION: These findings demonstrated that there were
no significant differences in the distribution of alpha1-AT
phenotypes among Jordanian patients with lung, prostate
and breast cancer and they matched those reported for healthy
individuals. Thus, we cannot recommend a given alpha1-AT
phenotype for early diagnosis of the above mentioned types of
Department of Biochemistry and Molecular Biology, Jordan
University of Science and Technology, School of
Medicine, Irbid 22110, Jordan.